Oat Beta Glucan Research

Nutrim ​and Cholesterol

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Oat-derived ß-Glucan Significantly Improves HDLC and Diminishes LDLC and Non-HDL Cholesterol in Overweight Individuals with Mild Hypercholestrolemia

Summary:  38 overweight men with high cholesterol were split equally placed on an AHA step II diet with either 6g of fiber from wheat bread or 6g ß-glucan from Nutrim® baked into bread. They were also instructed to walk for 60 minutes a day. At the end of 8 weeks the subjects had blood draws that were then compared to their initial blood work. The Nutrim® group saw significant improvement in lipid profile and body weight without any adverse effects.

​Oat Beta Glucan ​and Cholesterol

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Oat ß-Glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol execretion in ileostomy subjects

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​Oat ß-glucan mediates an increase in bile acid secretion, which most probably explains the effect of oat fiber in lowering cholesterol

Summary:  10 ileostomy patients were fed 4 diets, each for 2 days. The 4 diets included 4 different types of bread: oat bran, oat bran with ß-glucanase (an enzyme that breaks down ß-glucans), barley, and wheat. Feeding oat bran bread resulted in a 53% higher bile acid secretion compared to oat bran bread with ß-glucanase. Oat bran bread also resulted in significantly more excretion of bile acids compared with barley and wheat breads.

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Effects of oat gum on the physical properties of the gastrointestinal contents and on the uptake of D-galactose and cholesterol by rat small intestine in vitro

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​…increased viscosity of the contents of the small intestine may contribute to the low glycemic index and hypocholesterolaemic effects of oats in man

Summary:  Wister rats were fed 3 meals of either a control diet, a diet containing oat gum (ß-glucan), or finely ground rolled oats. The oat meals increased intestinal viscosity and wet to dry ratio of digestive tract contents. Cholesterol uptake and sugar was inhibited by oat gum.

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​ß-Glucan incorporated into a fruit drink effectively lowers serum LDL cholesterol concentrations

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​A reduced cholesterol absorption contributes to the cholesterol lowering effect of ß-glucans without affecting plasma concentrations of lipid soluble antioxidants.

Summary: 22 participants consumed 5g of rice starch and 25 participants consumed 5 g of ß-glucans from oats for 3 weeks. The ß-glucan group lowered total and LDL cholesterol. Cholesterol absorption was reduced without reducing absorption of fat soluble antioxidants.

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​Cholesterol lowering benefits of oat-containing cereal in Hispanic Americans

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​Consumption of oat cereal was associated with a reduction in plasma levels of both total cholesterol and LDL-c.

Summary:  152 men and women were randomly assigned to eat 3g ß- glucans from oat cereal or corn cereal. The ß-glucan group significantly lowered total and LDL cholesterol while corn slightly raised cholesterol.

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​Effects of oat bran enriched diet on the atherogenic lipid profile in patients with an increased coronary heart disease risk. A controlled randomized lifestyle intervention study

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​…oat bran, within a practical range of intake significantly reduces total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B… independant of covariables such as physical activity or caloric and fat restriction in the diet.

Summary:  99 patients received a fat modified diet with caloric restriction, exercise, and health education along with 35-50g of oat bran per day, while 136 men received the same diet and lifestyle program without oat bran. 53 men served as controls. A significant reduction was seen in the oat bran group for total (-67.7 mg/dl) and LDL cholesterol(-56.3mg/dl), as well as a reduction in apolipoprotein(-42.4mg/dl).

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​Oat ß-glucan reduces blood cholesterol concentrations in hypercholesterolemic subjects

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​The main component of the soluble fiber of oats, ß-glucan, significantly reduced the total and LDL cholesterol levels of hypercholesterolemic adults…

Summary:  A crossover study was carried out with 19 Men and women who were fed either 2.9g ß-glucan twice per day or a placebo for 4 weeks. The placebo made no significant changes in cholesterol while the ß-glucan reduced total and LDL cholesterol.

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​Concentrated oat ß-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial

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​Thus, a practical dose of β-glucan can significantly lower serum lipids in a high-risk population and may improve colon health.

Summary:  75 men and women were randomly assigned to either 6g/day of oat ß-glucan or 6 grams/day of dextrose for 6 weeks.  The ß-glucan group saw significant decreases in total and LDL cholesterol compared with the placebo group.